UV radiation
Damages DNA and repair mechanisms
RF for SCC, basal cell, and melanoma
Melanin single best factor for protecting skin from UV radiation. Absorbs radiation and dissipates as heat
UV-A - causes skin aging/wrinkling. Also has some part in CA. Responsible for tanning
UV-B - causes SKIN DAMAGE, sunburn, and has greatest damage to DNA and role in causing cancer
Xanthoma - cholesterol rich, yellow, contains histiocytes. Benign
Neuroma – associated with NF/von Recklinghausen’s, peripheral and CNS tumor
Suspicious skin lesion
- For most soft tissue tumor start with Core needle vs Punch biopsy
- Start with incisional biopsy (SCC and BCC) UNLESS concerned about melanoma, ****then you MUST do full thickness punch biopsy first and make sure to get down to SUBQ FAT
- If that is non-diagnostic, then do incisional biopsy
- Melanoma
- Subungal melanoma
- Basal cell cancer
- Squamous cell cancer
- Marjolin ulcer
- Keratosis
- Keratoacanthoma
- Merkel cell carcinoma of skin
- Glomus tumor
- Paraganglioma
Moh’s Surgery
- Confirms complete excision, takes as little tissue as possible
- Indications**: > 2 cm** or cosmetically sensitive areas or positive margins after excision