• ITP - caused by IgG against fibrinogen receptor glycoprotein IIb/IIIa and IR/IX [8/23]
• ITP - plt transfusion indication [9/6]
• TTP - widespread thrombosis, ADAMTS13. Thrombocytopenic purpura, neurologic manifestations, kidney injury, hemolytic anemia, fever [MOCK ABSITE]
• Vaccine timing s/p emergency splenectomy - 2 wks [10/30]

Results of splenectomy/hyposplenism:

Transient increase in platelet, RBC and WBC

Persistent increase in lymphocytes and monocytes

Minimum age of splenectomy is 5 years old

Almost always need splenectomy for:

• Hereditary spherocytosis and eliptococytosis
• Echinococcal cyst
• Dermoid cyst
• Multiloculated splenic abscess

Usually need splenectomy:

• Refractory warm antibody hemolytic anemia
• Refractory ITP
• Isolated splenic lymphoma (splenomegaly)
• Myelofibrosis with splenic myeloid metaplasia (spleen acts as bone marrow) Tx: splenectomy if transfusion dependent or severe thrombocytopenia
• ITP
• TTP
• Hereditary Spherocytosis
• Hemolytic anemias
• Splenic cyst
• Hodgkin Lymphoma
• Felty’s syndrome
• Wandering spleen
• Splenic abscess
• Post splenectomy follow up
• OPSI (Post-Splenectomy Sepsis)
• Post-splenectomy Complications